王欣玲
年级：2018级博士| Email：18111010064@fudan.edu.cn|家乡：安徽
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教育背景
2009年-2014年皖南医学院预防医学专业本科
2014年-2017年中国疾病预防控制中心免疫学专业硕士
2018年-2021年 复旦大学病原生物学专业博士
研究方向
抗感染生物治疗及活性蛋白药物研究
研究生期间发表论文
1: Guo L, Bi W, Wang X, Xu W, Yan R, Zhang Y, Zhao K, Li Y, Zhang M, Cai X,
Jiang S, Xie Y, Zhou Q, Lu L, Dang B. Engineered trimeric ACE2 binds viral spike
protein and locks it in Three-up conformation to potently inhibit SARS-CoV-2
infection. Cell Res. 2021 Jan;31(1):98-100. doi: 10.1038/s41422-020-00438-w.
Epub 2020 Nov 11. PMID: 33177651; PMCID: PMC7656503.
2: Wang C, Wang X, Wang H, Pu J, Li Q, Li J, Liu Y, Lu L, Jiang S. A Two-Birds-
One-Stone Approach toward the Design of Bifunctional Human Immunodeficiency
Virus Type 1 Entry Inhibitors Targeting the CCR5 Coreceptor and gp41 N-Terminal
Heptad Repeat Region. J Med Chem. 2021 Aug 12;64(15):11460-11471. doi:
10.1021/acs.jmedchem.1c00781. Epub 2021 Jul 15. PMID: 34261320.
3: Liu Z, Xia S, Wang X, Lan Q, Xu W, Wang Q, Jiang S, Lu L. Inefficiency of
Sera from Mice Treated with Pseudotyped SARS-CoV to Neutralize 2019-nCoV
Infection. Virol Sin. 2020 Jun;35(3):340-343. doi: 10.1007/s12250-020-00214-5.
Epub 2020 Mar 31. PMID: 32236815; PMCID: PMC7105968.
4: Xue S, Xu W, Wang L, Wang X, Duan Q, Calcul L, Wang S, Liu W, Sun X, Lu L,
Jiang S, Cai J. An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-
coronavirus Fusion Inhibitor with Strong Blood-Brain Barrier Permeability, Long
Half-Life, and Promising Oral Bioavailability. ACS Cent Sci. 2023 Apr
28;9(5):1046-1058. doi: 10.1021/acscentsci.3c00313. PMID: 37252367; PMCID:
PMC10184535.
5: Wang X, Cao M, Wu Y, Xu W, Wang Q, Ying T, Lu L, Jiang S. Synergistic Effect
by Combining a gp120-Binding Protein and a gp41-Binding Antibody to Inactivate
HIV-1 Virions and Inhibit HIV-1 Infection. Molecules. 2021 Mar 31;26(7):1964.
doi: 10.3390/molecules26071964. PMID: 33807292; PMCID: PMC8036483.
6: Wang X, Xu W, Hu G, Xia S, Sun Z, Liu Z, Xie Y, Zhang R, Jiang S, Lu L.
RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-
mediated membrane fusion. Cell Mol Immunol. 2020 Apr 7;20(5):554. doi:
10.1038/s41423-020-0424-9. Epub ahead of print. Retraction in: Cell Mol Immunol.
2020 Aug;17(8):894. PMID: 32265513; PMCID: PMC7136698.
7: Wang C, Xia S, Wang X, Li Y, Wang H, Xiang R, Jiang Q, Lan Q, Liang R, Li Q,
Huo S, Lu L, Wang Q, Yu F, Liu K, Jiang S. Supercoiling Structure-Based Design
of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human
β-Coronavirus Infection. J Med Chem. 2022 Feb 24;65(4):2809-2819. doi:
10.1021/acs.jmedchem.1c00258. Epub 2021 Apr 30. PMID: 33929200; PMCID:
PMC8117781.
8: Wang C, Wang H, Wang X, Sun L, Wang Q, Li Q, Liang R, Dou D, Yu F, Lu L,
Jiang S. Multitargeted drug design strategy for discovery of short-peptide-based
HIV-1 entry inhibitors with high potency. Eur J Med Chem. 2023 Apr 5;252:115294.
doi: 10.1016/j.ejmech.2023.115294. Epub 2023 Mar 16. PMID: 36944281.
9: Liu Z, Zhou J, Wang X, Xu W, Teng Z, Chen H, Chen M, Zhang G, Wang Y, Huang
J, Wang Q, Jiang S, Lu L. A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2
original strain elicits potent neutralizing antibodies against XBB in non-human
primates. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2221713120. doi:
10.1073/pnas.2221713120. Epub 2023 Mar 10. PMID: 36897979.
10: Huang M, Pan X, Wang X, Ren Q, Tong B, Dong X, Ge G, Lu L, Jiang S, Chen J.
Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2.
Signal Transduct Target Ther. 2023 Feb 27;8(1):84. doi:
10.1038/s41392-023-01348-0. PMID: 36849525; PMCID: PMC9969015.
11: Wang H, Wang X, Li J, Li Q, Feng S, Lu L, Wang C, Jiang S. Design of
artificial α-helical peptides targeting both gp41 deep pocket and subpocket as
potent HIV-1 fusion inhibitors. Eur J Med Chem. 2022 Jun 5;236:114336. doi:
10.1016/j.ejmech.2022.114336. Epub 2022 Apr 1. PMID: 35395438.
12: Liu Z, Xia S, Wang X, Lan Q, Li P, Xu W, Wang Q, Lu L, Jiang S. Sodium
Copper Chlorophyllin Is Highly Effective against Enterovirus (EV) A71 Infection
by Blocking Its Entry into the Host Cell. ACS Infect Dis. 2020 May
8;6(5):882-890. doi: 10.1021/acsinfecdis.0c00096. Epub 2020 Apr 10. PMID:
32233455.
13: Wang X, Xu W, Liu Z, Wu Y, Wang Q, Cao M, Ying T, He N, Lu L, Jiang S. A
Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating
HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells.
mBio. 2022 Feb 22;13(1):e0338421. doi: 10.1128/mbio.03384-21. Epub 2022 Jan 18.
PMID: 35038908; PMCID: PMC8764533.
14: Wang X, Xia S, Zhu Y, Lu L, Jiang S. Pan-coronavirus fusion inhibitors as
the hope for today and tomorrow. Protein Cell. 2021 Feb;12(2):84-88. doi:
10.1007/s13238-020-00806-7. Epub 2021 Jan 9. PMID: 33420956; PMCID: PMC7796682.
15: Xue S, Wang X, Wang L, Xu W, Xia S, Sun L, Wang S, Shen N, Yang Z, Huang B,
Li S, Cao C, Calcul L, Sun X, Lu L, Cai J, Jiang S. A novel cyclic γ-AApeptide-
based long-acting pan-coronavirus fusion inhibitor with potential oral
bioavailability by targeting two sites in spike protein. Cell Discov. 2022 Sep
8;8(1):88. doi: 10.1038/s41421-022-00455-6. PMID: 36075899; PMCID: PMC9453727.
16: Wang X, Liu Z, Lu L, Jiang S. The putative mechanism of lymphopenia in
COVID-19 patients. J Mol Cell Biol. 2022 Aug 26;14(5):mjac034. doi:
10.1093/jmcb/mjac034. PMID: 35641108; PMCID: PMC9412754.
17: Wang X, Xia S, Wang Q, Xu W, Li W, Lu L, Jiang S. Broad-Spectrum Coronavirus
Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases.
Int J Mol Sci. 2020 May 28;21(11):3843. doi: 10.3390/ijms21113843. PMID:
32481690; PMCID: PMC7311999.
18: Wang X, Xu W, Hu G, Xia S, Sun Z, Liu Z, Xie Y, Zhang R, Jiang S, Lu L.
Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-
mediated membrane fusion. Cell Mol Immunol. 2020 Aug;17(8):894. doi:
10.1038/s41423-020-0498-4. PMID: 32651469; PMCID: PMC7348563.
19: Liu Z, Xu W, Xia S, Gu C, Wang X, Wang Q, Zhou J, Wu Y, Cai X, Qu D, Ying T,
Xie Y, Lu L, Yuan Z, Jiang S. RBD-Fc-based COVID-19 vaccine candidate induces
highly potent SARS-CoV-2 neutralizing antibody response. Signal Transduct Target
Ther. 2020 Nov 27;5(1):282. doi: 10.1038/s41392-020-00402-5. PMID: 33247109;
PMCID: PMC7691975.
20: Liu Z, Zhou J, Xu W, Deng W, Wang Y, Wang M, Wang Q, Hsieh M, Dong J, Wang
X, Huang W, Xing L, He M, Tao C, Xie Y, Zhang Y, Wang Y, Zhao J, Yuan Z, Qin C,
Jiang S, Lu L. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits
potent and durable neutralizing antibody and T cell responses in mice, rabbits
and NHPs. Cell Res. 2022 Mar;32(3):269-287. doi: 10.1038/s41422-022-00612-2.
Epub 2022 Jan 19. PMID: 35046518; PMCID: PMC8767042.
21: Xia S, Lan Q, Su S, Wang X, Xu W, Liu Z, Zhu Y, Wang Q, Lu L, Jiang S. The
role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion
in the presence or absence of trypsin. Signal Transduct Target Ther. 2020 Jun
12;5(1):92. doi: 10.1038/s41392-020-0184-0. PMID: 32532959; PMCID: PMC7289711.
22: Wang C, Li Q, Sun L, Wang X, Wang H, Zhang W, Li J, Liu Y, Lu L, Jiang S. An
Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with
Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the
Host Cell Membrane. Viruses. 2023 Apr 23;15(5):1038. doi: 10.3390/v15051038.
PMID: 37243126; PMCID: PMC10223265.
获奖情况
上海市优秀毕业生
